Activities, substrate specificity, and genetic interactions of fission yeast Siw14, a cysteinyl-phosphatase-type inositol pyrophosphatase

ABSTRACT Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,5-IP8 and two pyrophosphatases—the A...

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Bibliographic Details
Main Authors: Ana M. Sanchez, Beate Schwer, Nikolaus Jork, Henning J. Jessen, Stewart Shuman
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mbio.02056-23