BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL‐induced DNA damage and endothelial apoptosis

BReast CAncer susceptibility gene 2 deficiency exacerbates oxidized LDL‐induced DNA damage and endothelial apoptosis

Abstract Mutations in the tumor suppressor gene BRCA2 (BReast CAncer susceptibility gene 2) predispose carriers to breast, ovarian, and other cancers. In response to DNA damage, BRCA2 participates in homology‐directed DNA damage repair to maintain genome stability. Genome‐wide association studies ha...

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Bibliographic Details
Main Authors: Shweta Singh, Hien Nguyen, David Michels, Hannah Bazinet, Pratiek N. Matkar, Zongyi Liu, Lilian Esene, Mohamed Adam, Antoinette Bugyei‐Twum, Elizabeth Mebrahtu, Jameela Joseph, Mehroz Ehsan, Hao H. Chen, Mohammad Qadura, Krishna K. Singh
Format: Article
Language:English
Published: Wiley 2020-07-01
Series:Physiological Reports
Subjects:
BRCA2
DNA damage
endothelial cell
endothelial dysfunction
oxidative stress
Online Access:https://doi.org/10.14814/phy2.14481

Internet

https://doi.org/10.14814/phy2.14481

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