Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibody

Identification and characterization of M6903, an antagonistic anti–TIM-3 monoclonal antibody

T cell immunoglobulin and mucin domain-3 (TIM-3) is an immune checkpoint that regulates normal immune responses but can be exploited by tumor cells to evade immune surveillance. TIM-3 is primarily expressed on immune cells, particularly on dysfunctional and exhausted T cells, and engagement of TIM-3...

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Bibliographic Details
Main Authors: Dong Zhang, Feng Jiang, Rinat Zaynagetdinov, Hui Huang, Vanita D. Sood, Hong Wang, Xinyan Zhao, Molly H. Jenkins, Qingyong Ji, Youbin Wang, David P. Nannemann, Djordje Musil, John Wesolowski, Andrea Paoletti, Tin Bartholomew, Melissa G. Derner, Qi An, Christel Iffland, Joern-Peter Halle
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
tim-3
ptdser
gal-9
ceacam1
antagonistic antibody
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1744921

Internet

http://dx.doi.org/10.1080/2162402X.2020.1744921

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