Glutamate’s Effects on the N-Methyl-D-Aspartate (NMDA) Receptor Ion Channel in Alzheimer’s Disease Brain: Challenges for PET Radiotracer Development for Imaging the NMDA Ion Channel

Glutamate’s Effects on the N-Methyl-D-Aspartate (NMDA) Receptor Ion Channel in Alzheimer’s Disease Brain: Challenges for PET Radiotracer Development for Imaging the NMDA Ion Channel

In an effort to further understand the challenges facing in vivo imaging probe development for the N-methyl-D-aspartate (NMDA) receptor ion channel, we have evaluated the effect of glutamate on the Alzheimer’s disease (AD) brain. Human post-mortem AD brain slices of the frontal cortex and anterior c...

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Bibliographic Details
Main Authors: Nehal M. Shah, Nane Ghazaryan, Noresa L. Gonzaga, Cayz G. Paclibar, Agnes P. Biju, Christopher Liang, Jogeshwar Mukherjee
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
NMDA ion channel
glutamate
MK-801
memantine
Alzheimer’s disease
PET imaging
Online Access:https://www.mdpi.com/1420-3049/29/1/20

Internet

https://www.mdpi.com/1420-3049/29/1/20

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