Evaluation of the Polygenic Risk Score for Alzheimer’s Disease in Russian Patients with Dementia Using a Low-Density Hydrogel Oligonucleotide Microarray

Evaluation of the Polygenic Risk Score for Alzheimer’s Disease in Russian Patients with Dementia Using a Low-Density Hydrogel Oligonucleotide Microarray

The polygenic risk score (PRS), together with the <i>ɛ4</i> allele of the <i>APOE</i> gene (<i>APOE-ɛ4</i>), has shown high potential for Alzheimer’s disease (AD) risk prediction. The aim of this study was to validate the model of polygenic risk in Russian patient...

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Bibliographic Details
Main Authors: Anna Ikonnikova, Anna Morozova, Olga Antonova, Alexandra Ochneva, Elena Fedoseeva, Olga Abramova, Marina Emelyanova, Marina Filippova, Irina Morozova, Yana Zorkina, Timur Syunyakov, Alisa Andryushchenko, Denis Andreuyk, Georgy Kostyuk, Dmitry Gryadunov
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
dementia
polygenic risk
Alzheimer’s disease
<i>APOE</i>
microarray
genetic risk
Online Access:https://www.mdpi.com/1422-0067/24/19/14765

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https://www.mdpi.com/1422-0067/24/19/14765

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