Context Matters: Response Heterogeneity to Collagen-Targeting Approaches in Desmoplastic Cancers

Context Matters: Response Heterogeneity to Collagen-Targeting Approaches in Desmoplastic Cancers

The deposition of collagen-rich desmoplastic tissue is a well-documented feature of the solid tumor microenvironment (TME). However, efforts to target the desmoplastic extracellular matrix (ECM) en masse, or collagen molecules more specifically, have been met with mixed and sometimes paradoxical res...

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Bibliographic Details
Main Authors: Ashley M. Fuller, Tzipora S. Karin Eisinger-Mathason
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
desmoplasia
extracellular matrix
tumor microenvironment
stromal depletion
cancer-associated fibroblast
collagen biosynthesis
Online Access:https://www.mdpi.com/2072-6694/14/13/3132

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https://www.mdpi.com/2072-6694/14/13/3132

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