Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID)

Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID)

IntroductionCommon variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy (IgRT) can prevent severe infections but not underl...

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Bibliographic Details
Main Authors: Remo Poto, Antonio Pecoraro, Anne Lise Ferrara, Alessandra Punziano, Gianluca Lagnese, Carla Messuri, Stefania Loffredo, Giuseppe Spadaro, Gilda Varricchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
common variable immunodeficiency
CVID
lipopolysaccharide
IL-1
TNF-α
IL-6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1257398/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1257398/full

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