Focused Design of Novel Cyclic Peptides Endowed with GABARAP-Inhibiting Activity

Focused Design of Novel Cyclic Peptides Endowed with GABARAP-Inhibiting Activity

(1) Background: Disfunctions in autophagy machinery have been identified in various conditions, including neurodegenerative diseases, cancer, and inflammation. Among mammalian autophagy proteins, the Atg8 family member GABARAP has been shown to be greatly involved in the autophagy process of prostat...

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Bibliographic Details
Main Authors: Enrico Mario Alessandro Fassi, Mariangela Garofalo, Jacopo Sgrignani, Michele Dei Cas, Matteo Mori, Gabriella Roda, Andrea Cavalli, Giovanni Grazioso
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
peptide
GABARAP inhibitors
autophagy
cancer
Atg8
LIR motif
Online Access:https://www.mdpi.com/1422-0067/23/9/5070

Internet

https://www.mdpi.com/1422-0067/23/9/5070

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