Signal Suppression in LC-ESI-MS/MS from Concomitant Medications and Its Impact on Quantitative Studies: An Example Using Metformin and Glyburide

Signal Suppression in LC-ESI-MS/MS from Concomitant Medications and Its Impact on Quantitative Studies: An Example Using Metformin and Glyburide

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been widely used in the quantitative analysis of drugs. The ubiquitous concomitant drug scenario in the clinic has spawned a large number of co-analyses based on this technique. However, signal suppression caused by concomitant drugs duri...

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Bibliographic Details
Main Authors: Jingyu Liu, Fulin Jiang, Zihan Lu, Chang Zhang, Peiqing Liu, Min Huang, Guoping Zhong
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
liquid chromatography-tandem mass spectrometry
concomitant medication
signal suppression
quantitative analysis
Online Access:https://www.mdpi.com/1420-3049/28/2/746

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https://www.mdpi.com/1420-3049/28/2/746

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