In Vitro and in Vivo Assays of 3,5-Disubstituted-Tetrahydro-2H-1,3,5-Thiadiazin-2-Thione Derivatives against Trypanosoma cruzi

In Vitro and in Vivo Assays of 3,5-Disubstituted-Tetrahydro-2H-1,3,5-Thiadiazin-2-Thione Derivatives against Trypanosoma cruzi

Cytotoxicity assays of 24 new 3,5-disubstituted-tetrahydro-2H-1,3,5-thiadiazin-2-thione derivatives were performed. The 17 compounds with higher anti-epimastigote activity and lower cytotoxicity were, thereafter, screened against amastigote of Trypanosoma cruzi. Out of these 17 derivatives S-2d was...

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Bibliographic Details
Main Authors: Susana Muelas, Margarita Suárez, Rolando Pérez, Hortensia Rodríguez, Carmen Ochoa, José Antonio Escario, Alicia Gómez-Barrio
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2002-03-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
antichagasic drugs
amastigotes
J774 macrophages
cytotoxicity assays
antitrypanosomal activity assays
thiadiazine thione derivatives
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000200023

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762002000200023

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