Morroniside ameliorates inflammatory skeletal muscle atrophy via inhibiting canonical and non-canonical NF-κB and regulating protein synthesis/degradation

Morroniside ameliorates inflammatory skeletal muscle atrophy via inhibiting canonical and non-canonical NF-κB and regulating protein synthesis/degradation

No drug options exist for skeletal muscle atrophy in clinical, which poses a huge socio-economic burden, making development on drug interventions a general wellbeing need. Patients with a variety of pathologic conditions associated with skeletal muscle atrophy have systemically elevated inflammatory...

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Bibliographic Details
Main Authors: Xiangjiao Yi, Jianguo Tao, Yu Qian, Feng Feng, Xueqin Hu, Taotao Xu, Hongting Jin, Hongfeng Ruan, Hou-Feng Zheng, Peijian Tong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
morroniside
muscle atrophy
denervation
inflammation
autophagylysosomal pathway
ubiquitin-proteasome system
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1056460/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1056460/full

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