Estimating Phred scores of Illumina base calls by logistic regression and sparse modeling

Estimating Phred scores of Illumina base calls by logistic regression and sparse modeling

Abstract Background Phred quality scores are essential for downstream DNA analysis such as SNP detection and DNA assembly. Thus a valid model to define them is indispensable for any base-calling software. Recently, we developed the base-caller 3Dec for Illumina sequencing platforms, which reduces ba...

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Bibliographic Details
Main Authors: Sheng Zhang, Bo Wang, Lin Wan, Lei M. Li
Format: Article
Language:English
Published: BMC 2017-07-01
Series:BMC Bioinformatics
Subjects:
Base-calling
Logistic regression
Quality score
L 1 regularization
AIC
BIC
Online Access:http://link.springer.com/article/10.1186/s12859-017-1743-4

Internet

http://link.springer.com/article/10.1186/s12859-017-1743-4

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