Modeling complement activation on human glomerular microvascular endothelial cells

Modeling complement activation on human glomerular microvascular endothelial cells

IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glomerular endothelium. To further understand aHUS pathophysiology, we validated an ex vivo m...

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Bibliographic Details
Main Authors: Kes H. Stevens, Laura M. Baas, Thea J. A. M. van der Velden, Romy N. Bouwmeester, Niels van Dillen, Eiske M. Dorresteijn, Arjan D. van Zuilen, Jack F. M. Wetzels, Marloes A. H. M. Michels, Nicole C. A. J. van de Kar, Lambertus P. van den Heuvel
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Immunology
Subjects:
alternative pathway
atypical hemolytic uremic syndrome
C5b-9
complement system
eculizumab
glomerular endothelium
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206409/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1206409/full

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