The endothelin receptor antagonist macitentan ameliorates endothelin-mediated vasoconstriction and promotes the survival of retinal ganglion cells in rats

The endothelin receptor antagonist macitentan ameliorates endothelin-mediated vasoconstriction and promotes the survival of retinal ganglion cells in rats

Glaucoma is a chronic and progressive eye disease, commonly associated with elevated intraocular pressure (IOP) and characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells (RGCs). The pathological changes in glaucoma are triggered by multiple mechanis...

Full description

Bibliographic Details
Main Authors: Bindu Kodati, Wei Zhang, Shaoqing He, Jennifer H. Pham, Kallen J. Beall, Zoe E. Swanger, Vignesh R. Krishnamoorthy, Payton E. Harris, Trent Hall, Ashley V. Tran, Renuka M. Chaphalkar, Sai H. Chavala, Dorota L. Stankowska, Raghu R. Krishnamoorthy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Ophthalmology
Subjects:
glaucoma
endothelins
vasoconstriction
macitentan
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fopht.2023.1185755/full

Internet

https://www.frontiersin.org/articles/10.3389/fopht.2023.1185755/full

Similar Items