The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway

In this study, we analyzed whether ER Ca2+ release, induced by amyloid-β (Aβ) and prion (PrP) peptides activates the mitochondrial-mediated apoptotic pathway. In cortical neurons, addition of the synthetic Aβ1–40 or PrP106–126 peptides depletes ER Ca2+ content, leading to cytosolic Ca2+ overload. Th...

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Bibliographic Details
Main Authors: Elisabete Ferreiro, Catarina R. Oliveira, Cláudia M.F. Pereira
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Prion disorders
Amyloid-β
peptide
Prion peptide
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000284

Internet

http://www.sciencedirect.com/science/article/pii/S0969996108000284

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