Construction and Verification of a Fibroblast-Related Prognostic Signature Model for Colon Cancer

Construction and Verification of a Fibroblast-Related Prognostic Signature Model for Colon Cancer

Traditionally, cancer-associated fibroblasts (CAFs), an essential component of tumor microenvironment, were exert a crucial part in colon cancer progression. In this study, single-cell RNA-sequencing (scRNA-seq) data from 23 and bulk RNA-seq data from 452 colon cancer patients were extracted from th...

Full description

Bibliographic Details
Main Authors:	Zhe Zhao, Wenqi Li, LiMeng Zhu, Bei Xu, Yudong Jiang, Nan Ma, LiQun Liu, Jie Qiu, Min Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-07-01
Series:	Frontiers in Genetics
Subjects:	single-cell RNA-sequencing(scRNA-seq) colon cancer cancer-associated fibroblasts (CAFs) immune infiltration drug sensitivity
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2022.908957/full

Similar Items

Single-Cell Transcriptomic Analysis of Tumor-Derived Fibroblasts and Normal Tissue-Resident Fibroblasts Reveals Fibroblast Heterogeneity in Breast Cancer
by: Aimy Sebastian, et al.
Published: (2020-05-01)

Integrated single-cell RNA-seq analysis reveals the vital cell types and dynamic development signature of atherosclerosis
by: Xiuli Shao, et al.
Published: (2023-03-01)

A novel enterocyte-related 4-gene signature for predicting prognosis in colon adenocarcinoma
by: Xuehua Cheng, et al.
Published: (2022-12-01)

Dissecting pulmonary fibroblasts heterogeneity in lung development, health and diseases
by: Xinxin Zhang, et al.
Published: (2023-09-01)

Integrative analysis of cancer-associated fibroblast signature in gastric cancer
by: Zidan Zhao, et al.
Published: (2023-09-01)

Single-cell transcriptome reveals Staphylococcus aureus modulating fibroblast differentiation in the bone-implant interface
by: Jinlong Yu, et al.
Published: (2023-03-01)

Integrating single-cell and bulk transcriptomic analyses to develop a cancer-associated fibroblast-derived biomarker for predicting prognosis and therapeutic response in breast cancer
by: Chunzhen Li, et al.
Published: (2024-01-01)

Microglial subpopulations with distinct transcriptome signatures vary across brain regions in the resting mouse brain
by: Rei Mishima, et al.
Published: (2023-03-01)

scCGImpute: An Imputation Method for Single-Cell RNA Sequencing Data Based on Similarities between Cells and Relationships among Genes
by: Tiantian Liu, et al.
Published: (2023-07-01)

Interpretation of the Yak Skin Single-Cell Transcriptome Landscape
by: Qingbo Zheng, et al.
Published: (2023-12-01)

GITR and TIGIT immunotherapy provokes divergent multicellular responses in the tumor microenvironment of gastrointestinal cancers
by: Anuja Sathe, et al.
Published: (2023-11-01)

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer
by: Xiaofan Sun, et al.
Published: (2023-07-01)

Methods, Challenges and Potentials of Single Cell RNA-seq
by: Daniel Hebenstreit
Published: (2012-11-01)

Insights gained from single-cell RNA analysis of murine endothelial cells in aging hearts
by: Zhong Liu, et al.
Published: (2023-08-01)

CXCL11 Correlates With Antitumor Immunity and an Improved Prognosis in Colon Cancer
by: Yingying Cao, et al.
Published: (2021-03-01)

Forward single‐cell sequencing into clinical application: Understanding of ageing and rejuvenation from clinical observation to single‐cell solution
by: Furong Yan, et al.
Published: (2022-06-01)

Identification of a novel signature based on macrophage-related marker genes to predict prognosis and immunotherapeutic effects in hepatocellular carcinoma
by: Yuanshuai Su, et al.
Published: (2023-05-01)

Advances in single-cell RNA sequencing and its applications in cancer research
by: Dezhi Huang, et al.
Published: (2023-08-01)

Single-cell transcriptome analysis reveals liver injury induced by glyphosate in mice
by: Jiangpeng Wu, et al.
Published: (2023-02-01)

baredSC: Bayesian approach to retrieve expression distribution of single-cell data
by: Lucille Lopez-Delisle, et al.
Published: (2022-01-01)

Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression
by: Kai Chen, et al.
Published: (2021-04-01)

Single-cell transcriptome sequencing reveals tumor heterogeneity in family neuroblastoma
by: Yunlong Zhang, et al.
Published: (2023-09-01)

Single-cell Transcriptomics Reveals Early Molecular and Immune Alterations Underlying the Serrated Neoplasia Pathway Toward Colorectal CancerSummary
by: Yu-Jie Zhou, et al.
Published: (2023-01-01)

Patterns, Profiles, and Parsimony: Dissecting Transcriptional Signatures From Minimal Single-Cell RNA-Seq Output With SALSA
by: Oswaldo A. Lozoya, et al.
Published: (2020-10-01)

Single‐cell analyses reveal suppressive tumor microenvironment of human colorectal cancer
by: Yan Mei, et al.
Published: (2021-06-01)

PDIA5 is Correlated With Immune Infiltration and Predicts Poor Prognosis in Gliomas
by: Hao Zhang, et al.
Published: (2021-02-01)

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells
by: Xinbo Wang, et al.
Published: (2022-06-01)

Molecular signatures distinguish senescent cells from inflammatory cells in aged mouse callus stromal cells
by: Jiatong Liu, et al.
Published: (2023-02-01)

High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labeling
by: Peibo Xu, et al.
Published: (2024-02-01)

Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic model
by: Zhiyong Tan, et al.
Published: (2023-03-01)

Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis
by: Minxue Jia, et al.
Published: (2023-04-01)

Single-Cell Analysis of Primary Liver Cancer in Mouse Models
by: Tina Suoangbaji, et al.
Published: (2023-02-01)

Forward single‐cell sequencing into clinical application: Understanding of cancer microenvironment at single‐cell solution
by: Xuanqi Liu, et al.
Published: (2022-06-01)

Intestinal cellular heterogeneity and disease development revealed by single-cell technology
by: Yalong Wang, et al.
Published: (2022-09-01)

Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis
by: Lingkai Zhang, et al.
Published: (2021-12-01)

Decoding the tumor microenvironment and molecular mechanism: unraveling cervical cancer subpopulations and prognostic signatures through scRNA-Seq and bulk RNA-seq analyses
by: Zhiheng Lin, et al.
Published: (2024-02-01)

Single-Cell Transcriptome Analysis Reveals Changes of Tumor Immune Microenvironment in Oral Squamous Cell Carcinoma After Chemotherapy
by: Hao Song, et al.
Published: (2022-06-01)

The Transcriptional Cell Atlas of Testis Development in Sheep at Pre-Sexual Maturity
by: Yi Wu, et al.
Published: (2022-01-01)

Sex disparities revealed by single-cell and bulk sequencing and their impacts on the efficacy of immunotherapy in esophageal cancer
by: Huimeng Yan, et al.
Published: (2024-03-01)

Discovering Cellular Mitochondrial Heteroplasmy Heterogeneity with Single Cell RNA and ATAC Sequencing
by: Aidan S. Marshall, et al.
Published: (2021-06-01)