The novel 4-hydroxyphenylpyruvate dioxygenase inhibitors in vivo and in silico approach: 3D-QSAR analysis, molecular docking, bioassay and molecular dynamics

The novel 4-hydroxyphenylpyruvate dioxygenase inhibitors in vivo and in silico approach: 3D-QSAR analysis, molecular docking, bioassay and molecular dynamics

4-Hydroxyphenylpyruvate dioxygenase (HPPD) is not only an important target enzyme for the treatment of type I tyrosinemia, but also a new target for design bleaching herbicides, and it plays key role in the biosynthesis of tocopherol and plastoquinone. Thirty-six known active pyridine derivatives we...

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Bibliographic Details
Main Authors: Juan Shi, Li-Xia Zhao, Jia-Yu Wang, Tong Ye, Meng Wang, Shuang Gao, Fei Ye, Ying Fu
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Arabian Journal of Chemistry
Subjects:
HPPD inhibitors
3D-QSAR
Molecular docking
Molecular dynamics
Bioassay
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535222002350

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http://www.sciencedirect.com/science/article/pii/S1878535222002350

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