DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome—including in elderly patients

DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome—including in elderly patients

Abstract Elderly patients represent a growing proportion of individuals with glioblastoma, who however, are often excluded from clinical trials owing to poor expected prognosis. We aimed at identifying age-related molecular differences that would justify and guide distinct treatment decisions in eld...

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Bibliographic Details
Main Authors: Pierre Bady, Christine Marosi, Michael Weller, Bjørn H. Grønberg, Henrik Schultz, Martin J. B. Taphoorn, Johanna M. M. Gijtenbeek, Martin J. van den Bent, Andreas von Deimling, Roger Stupp, Annika Malmström, Monika E. Hegi
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Acta Neuropathologica Communications
Subjects:
DNA methylation age acceleration
Glioblastoma IDHwt
Survival
Methylome
Age
Online Access:https://doi.org/10.1186/s40478-022-01344-5

Internet

https://doi.org/10.1186/s40478-022-01344-5

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