Serum Insufficiency Induces RANKL-Independent Osteoclast Formation during Developing Ischemic ONFH

Serum Insufficiency Induces RANKL-Independent Osteoclast Formation during Developing Ischemic ONFH

Blood supply interruption induces hypoxia and reduces serum provision to cause ischemia-induced osteonecrosis, including avascular osteonecrosis of the femoral head (ONFH). Oxygen deficiency (hypoxia) is known to induce different expression patterns in osteoblasts and osteoclasts, which have been ex...

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Bibliographic Details
Main Authors: Yi-min Hsiao, Chih-Chien Hu, Mei-Feng Chen, Chih-Hsiang Chang, Yu-Tien Chiu, Yuhan Chang
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
ischemia
osteonecrosis
serum insufficiency
osteogenesis
osteoclast
Online Access:https://www.mdpi.com/2227-9059/9/6/685

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