Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk

Simple and validated method to quantify lacosamide in human breast milk and plasma using UPLC/MS/MS and its application to estimate drug transfer into breast milk

Abstract Background Epilepsy is a common neurological disorder. Lacosamide is a third-generation antiepileptic drug used to treat partial-onset seizures. Limited information is currently available on the transfer of lacosamide to breast milk. To facilitate studies on the safety of lacosamide use dur...

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Bibliographic Details
Main Authors: Ayako Furugen, Ayako Nishimura, Takeshi Umazume, Hina Ishikawa, Katsuya Narumi, Masaki Kobayashi
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Pharmaceutical Health Care and Sciences
Subjects:
Breast milk
Lacosamide
Milk to plasma ratio
Relative infant dose
UPLC/MS/MS
Online Access:https://doi.org/10.1186/s40780-023-00295-w

Internet

https://doi.org/10.1186/s40780-023-00295-w

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