MMP24 Contributes to Neuropathic Pain in an FTO-Dependent Manner in the Spinal Cord Neurons

MMP24 Contributes to Neuropathic Pain in an FTO-Dependent Manner in the Spinal Cord Neurons

Nerve injury-induced gene expression change in the spinal cord is critical for neuropathic pain genesis. RNA N6-methyladenosine (m6A) modification represents an additional layer of gene regulation. We showed that spinal nerve ligation (SNL) upregulated the expression of matrix metallopeptidase 24 (M...

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Bibliographic Details
Main Authors: Longfei Ma, Yangyuxin Huang, Fengjiang Zhang, Dave Schwinn Gao, Na Sun, Jinxuan Ren, Suyun Xia, Jia Li, Xinyi Peng, Lina Yu, Bao-Chun Jiang, Min Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
neuropathic pain
matrix metallopeptidase 24
fat-mass and obesity-associated protein
N6-methyladenosine
spinal cord
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.673831/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.673831/full

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