Molecular Targeting of the BRAF Proto-Oncogene/Mitogen-Activated Protein Kinase (MAPK) Pathway across Cancers

Molecular Targeting of the BRAF Proto-Oncogene/Mitogen-Activated Protein Kinase (MAPK) Pathway across Cancers

The mitogen-activated protein kinase (MAPK) pathway is essential for cellular proliferation, growth, and survival. Constitutive activation of this pathway by BRAF mutations can cause downstream activation of kinases, leading to uncontrolled cellular growth and carcinogenesis. Therefore, inhibition o...

Full description

Bibliographic Details
Main Authors: Khine S. Shan, Tauseef U. Rehman, Stan Ivanov, Gelenis Domingo, Luis E. Raez
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
BRAF
MEK
ERK
MAPK
molecular profiling
targeted therapy
Online Access:https://www.mdpi.com/1422-0067/25/1/624

Internet

https://www.mdpi.com/1422-0067/25/1/624

Similar Items