Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice

Dysfunctional cGMP Signaling Leads to Age-Related Retinal Vascular Alterations and Astrocyte Remodeling in Mice

The nitric oxide–guanylyl cyclase-1–cyclic guanylate monophosphate (NO–GC-1–cGMP) pathway is integral to the control of vascular tone and morphology. Mice lacking the alpha catalytic domain of guanylate cyclase (<i>GC1<sup>−/−</sup></i>) develop retinal ganglion cell (RGC) de...

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Bibliographic Details
Main Authors: Joseph M. Holden, Sara Al Hussein Al Awamlh, Louis-Philippe Croteau, Andrew M. Boal, Tonia S. Rex, Michael L. Risner, David J. Calkins, Lauren K. Wareham
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
retinal vasculature
neurovascular unit
blood retinal barrier
astrocyte
connexin
gap junctions
Online Access:https://www.mdpi.com/1422-0067/23/6/3066

Internet

https://www.mdpi.com/1422-0067/23/6/3066

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