PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

<p>Abstract</p> <p>The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular stresses. Recently, it has become widely appreciated that PARP-1 also participates in dive...

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Bibliographic Details
Main Authors: Alexander Jonathan S, Chaitanya Ganta, Babu Phanithi
Format: Article
Language:English
Published: BMC 2010-12-01
Series:Cell Communication and Signaling
Online Access:http://www.biosignaling.com/content/8/1/31