Imidazole-4-N-acetamide Derivatives as a Novel Scaffold for Selective Targeting of Cyclin Dependent Kinases

Imidazole-4-N-acetamide Derivatives as a Novel Scaffold for Selective Targeting of Cyclin Dependent Kinases

The rational design of cyclin-dependent protein kinase (CDK) inhibitors presumes the development of approaches for accurate prediction of selectivity and the activity of small molecular weight anticancer drug candidates. Aiming at attenuation of general toxicity of low selectivity compounds, we here...

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Bibliographic Details
Main Authors: Polina Rusina, Erik Gandalipov, Yana Abdusheva, Maria Panova, Alexandra Burdenkova, Vasiliy Chaliy, Maria Brachs, Oleg Stroganov, Ksenia Guzeeva, Igor Svitanko, Alexander Shtil, Fedor Novikov
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
cyclin dependent kinases
CDK1
CDK2
CDK5
CDK9
NEQ
Online Access:https://www.mdpi.com/2072-6694/15/15/3766

Internet

https://www.mdpi.com/2072-6694/15/15/3766

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