The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy
Epigenetic modifications may alter the proliferation and differentiation of normal cells, leading to malignant transformation. They can also affect normal stimulation, activation, and abnormal function of immune cells in the tissue microenvironment. Histone methylation, coordinated by histone methyl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1099892/full |
| _version_ | 1797956007790379008 |
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| author | Yuanling Zhang Yuanling Zhang Junhao Chen Hang Liu Rui Mi Rui Huang Xian Li Fei Fan Xueqing Xie Jie Ding |
| author_facet | Yuanling Zhang Yuanling Zhang Junhao Chen Hang Liu Rui Mi Rui Huang Xian Li Fei Fan Xueqing Xie Jie Ding |
| author_sort | Yuanling Zhang |
| collection | DOAJ |
| description | Epigenetic modifications may alter the proliferation and differentiation of normal cells, leading to malignant transformation. They can also affect normal stimulation, activation, and abnormal function of immune cells in the tissue microenvironment. Histone methylation, coordinated by histone methylase and histone demethylase to stabilize transcription levels in the promoter area, is one of the most common types of epigenetic alteration, which gained increasing interest. It can modify gene transcription through chromatin structure and affect cell fate, at the transcriptome or protein level. According to recent research, histone methylation modification can regulate tumor and immune cells affecting anti-tumor immune response. Consequently, it is critical to have a thorough grasp of the role of methylation function in cancer treatment. In this review, we discussed recent data on the mechanisms of histone methylation on factors associated with immune resistance of tumor cells and regulation of immune cell function. |
| first_indexed | 2024-04-10T23:42:04Z |
| format | Article |
| id | doaj.art-f26aae87050041428e1a4bf68a698825 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T23:42:04Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f26aae87050041428e1a4bf68a6988252023-01-11T06:46:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-01-011310.3389/fimmu.2022.10998921099892The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapyYuanling Zhang0Yuanling Zhang1Junhao Chen2Hang Liu3Rui Mi4Rui Huang5Xian Li6Fei Fan7Xueqing Xie8Jie Ding9School of Medicine, Guizhou University, Guiyang, ChinaDepartment of Gastrointestinal Surgery, Guizhou Provincial People’s Hospital, Guiyang, ChinaGraduate School of Zunyi Medical University, Zunyi, ChinaDepartment of Medical Cosmetology, Guizhou Provincial People’s Hospital, Guiyang, ChinaDepartment of General Surgery, Zhijin County People’s Hospital, Bijie, ChinaDepartment of Gastrointestinal Surgery, Guizhou Provincial People’s Hospital, Guiyang, ChinaOrthopedics Department, Dongguan Songshan Lake Tungwah Hospital, DongGuan, ChinaDepartment of Thyroid and Breast Surgery, Affiliated Hospital of Panzhihua University, Panzhihua, ChinaSchool of Medicine, Guizhou University, Guiyang, ChinaDepartment of Gastrointestinal Surgery, Guizhou Provincial People’s Hospital, Guiyang, ChinaEpigenetic modifications may alter the proliferation and differentiation of normal cells, leading to malignant transformation. They can also affect normal stimulation, activation, and abnormal function of immune cells in the tissue microenvironment. Histone methylation, coordinated by histone methylase and histone demethylase to stabilize transcription levels in the promoter area, is one of the most common types of epigenetic alteration, which gained increasing interest. It can modify gene transcription through chromatin structure and affect cell fate, at the transcriptome or protein level. According to recent research, histone methylation modification can regulate tumor and immune cells affecting anti-tumor immune response. Consequently, it is critical to have a thorough grasp of the role of methylation function in cancer treatment. In this review, we discussed recent data on the mechanisms of histone methylation on factors associated with immune resistance of tumor cells and regulation of immune cell function.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1099892/fullhistone methylationepigenetic modificationtumorantitumor immunityimmunotherapy |
| spellingShingle | Yuanling Zhang Yuanling Zhang Junhao Chen Hang Liu Rui Mi Rui Huang Xian Li Fei Fan Xueqing Xie Jie Ding The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy Frontiers in Immunology histone methylation epigenetic modification tumor antitumor immunity immunotherapy |
| title | The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy |
| title_full | The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy |
| title_fullStr | The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy |
| title_full_unstemmed | The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy |
| title_short | The role of histone methylase and demethylase in antitumor immunity: A new direction for immunotherapy |
| title_sort | role of histone methylase and demethylase in antitumor immunity a new direction for immunotherapy |
| topic | histone methylation epigenetic modification tumor antitumor immunity immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1099892/full |
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