Targeting tumor vulnerabilities associated with loss of heterozygosity
We show that N-acetyltransferase 2 (NAT2) loss of heterozygosity can be targeted in >4% of colorectal cancers with the use of a small molecule. We identify and describe the effect of a compound that impairs the growth of colorectal tumors with slow NAT2 activity by half when compared to wild-type...
| المؤلفون الرئيسيون: | , , |
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| التنسيق: | مقال |
| اللغة: | English |
| منشور في: |
Taylor & Francis Group
2020-07-01
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| سلاسل: | Molecular & Cellular Oncology |
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1080/23723556.2020.1759390 |