The discovery of the new mechanism: Celastrol improves spinal cord injury by increasing cAMP through VIP-ADCYAP1R1-GNAS pathway

The discovery of the new mechanism: Celastrol improves spinal cord injury by increasing cAMP through VIP-ADCYAP1R1-GNAS pathway

Spinal cord injury (SCI) is a debilitating condition that results in significant impairment of motor function and sensation. Despite the ongoing efforts to develop effective treatments, there are currently very limited options available for patients with SCI. Celastrol, a natural anti-inflammatory c...

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Bibliographic Details
Main Authors: Chuanhao Li, Wenyuan Shen, Zhengyu Xu, Chao Li, Quan Liu, Yilin Pang, Junjin Li, Xiaoyu Wang, Zhishuo Wang, Shiqing Feng
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Spinal cord injury
Celastrol
VIP
cAMP
JNK
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223010417

Internet

http://www.sciencedirect.com/science/article/pii/S0753332223010417

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