Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

During HIV infection, antiviral therapy can suppress viraemia to undetectable levels and hinder the progression towards AIDS; however the HIV-1 provirus can remain in long-lived CD4+ memory T cells. Here the authors show that intronic RNA from the HIV-1 provirus can induce type I interferon and infl...

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Bibliographic Details
Main Authors: Sean Matthew McCauley, Kyusik Kim, Anetta Nowosielska, Ann Dauphin, Leonid Yurkovetskiy, William Edward Diehl, Jeremy Luban
Format: Article
Language:English
Published: Nature Portfolio 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07753-2

Internet

https://doi.org/10.1038/s41467-018-07753-2

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