PTEN‐mediated dephosphorylation of 53BP1 confers cellular resistance to DNA damage in cancer cells

PTEN‐mediated dephosphorylation of 53BP1 confers cellular resistance to DNA damage in cancer cells

Homologous recombination (HR) repair for DNA double‐strand breaks (DSBs) is critical for maintaining genome stability and conferring the resistance of tumor cells to chemotherapy. Nuclear PTEN which contains both phosphatidylinositol 3,4,5‐trisphosphate 3‐phosphatase and protein phosphatase plays a...

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Bibliographic Details
Main Authors: Jianfeng He, Caihu Huang, Yanmin Guo, Rong Deng, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Junke Zheng, Xian Zhao, Jianxiu Yu
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Molecular Oncology
Subjects:
53BP1
DNA damage repair
homologous recombination (HR) repair
PTEN
SUMOylation
Online Access:https://doi.org/10.1002/1878-0261.13563

Internet

https://doi.org/10.1002/1878-0261.13563

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