Targeting endosomal pH for cancer chemotherapy

Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribu...

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Bibliographic Details
Main Authors: Fabrice Lucien, Roxane R. Lavoie, Claire M. Dubois
Format: Article
Language:English
Published: Taylor & Francis Group 2018-05-01
Series:Molecular & Cellular Oncology
Subjects:
Online Access:http://dx.doi.org/10.1080/23723556.2018.1435184