Targeting endosomal pH for cancer chemotherapy
Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2018.1435184 |
| _version_ | 1797677182251696128 |
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| author | Fabrice Lucien Roxane R. Lavoie Claire M. Dubois |
| author_facet | Fabrice Lucien Roxane R. Lavoie Claire M. Dubois |
| author_sort | Fabrice Lucien |
| collection | DOAJ |
| description | Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6). |
| first_indexed | 2024-03-11T22:41:20Z |
| format | Article |
| id | doaj.art-f277f12eceac40dbb32f7b5a70b904c8 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:20Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-f277f12eceac40dbb32f7b5a70b904c82023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-05-015310.1080/23723556.2018.14351841435184Targeting endosomal pH for cancer chemotherapyFabrice Lucien0Roxane R. Lavoie1Claire M. Dubois2University of SherbrookeUniversity of SherbrookeUniversity of SherbrookeAltered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribution of the endosomal pH regulator, the sodium/hydrogen exchanger 6 (NHE6).http://dx.doi.org/10.1080/23723556.2018.1435184nhe6solute carrier family 9 member a6 (slc9a6)chemoresistancedrug partitioningph-regulationendosomes |
| spellingShingle | Fabrice Lucien Roxane R. Lavoie Claire M. Dubois Targeting endosomal pH for cancer chemotherapy Molecular & Cellular Oncology nhe6 solute carrier family 9 member a6 (slc9a6) chemoresistance drug partitioning ph-regulation endosomes |
| title | Targeting endosomal pH for cancer chemotherapy |
| title_full | Targeting endosomal pH for cancer chemotherapy |
| title_fullStr | Targeting endosomal pH for cancer chemotherapy |
| title_full_unstemmed | Targeting endosomal pH for cancer chemotherapy |
| title_short | Targeting endosomal pH for cancer chemotherapy |
| title_sort | targeting endosomal ph for cancer chemotherapy |
| topic | nhe6 solute carrier family 9 member a6 (slc9a6) chemoresistance drug partitioning ph-regulation endosomes |
| url | http://dx.doi.org/10.1080/23723556.2018.1435184 |
| work_keys_str_mv | AT fabricelucien targetingendosomalphforcancerchemotherapy AT roxanerlavoie targetingendosomalphforcancerchemotherapy AT clairemdubois targetingendosomalphforcancerchemotherapy |