Targeting endosomal pH for cancer chemotherapy

Targeting endosomal pH for cancer chemotherapy

Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribu...

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Bibliographic Details
Main Authors:	Fabrice Lucien, Roxane R. Lavoie, Claire M. Dubois
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2018-05-01
Series:	Molecular & Cellular Oncology
Subjects:	nhe6 solute carrier family 9 member a6 (slc9a6) chemoresistance drug partitioning ph-regulation endosomes
Online Access:	http://dx.doi.org/10.1080/23723556.2018.1435184

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