Targeting endosomal pH for cancer chemotherapy

Targeting endosomal pH for cancer chemotherapy

Altered pH homeostasis in cancer cells has been linked with essentially all classical hallmarks of cancer, including chemoresistance. We recently identified a conceptually novel mechanism for how dysregulated pH in hypoxic cells causes chemoresistance which is based on the aberrant cellular distribu...

Podrobná bibliografie
Hlavní autoři:	Fabrice Lucien, Roxane R. Lavoie, Claire M. Dubois
Médium:	Článek
Jazyk:	English
Vydáno:	Taylor & Francis Group 2018-05-01
Edice:	Molecular & Cellular Oncology
Témata:	nhe6 solute carrier family 9 member a6 (slc9a6) chemoresistance drug partitioning ph-regulation endosomes
On-line přístup:	http://dx.doi.org/10.1080/23723556.2018.1435184

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