A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model

A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model

Abstract Background Wnt/β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been associated with pulmonary fibrosis, both in animal models and human diseases such as idiopathic pulmonary fibrosis (IPF). IPF is a detriment...

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Bibliographic Details
Main Authors: Mehaben Patel, Yorick Post, Natalie Hill, Asmiti Sura, Jay Ye, Trevor Fisher, Nicholas Suen, Mengrui Zhang, Leona Cheng, Ariel Pribluda, Hui Chen, Wen-Chen Yeh, Yang Li, Hélène Baribault, Russell B. Fletcher
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Respiratory Research
Subjects:
WNT mimetic
Wnt signaling
Pulmonary fibrosis
IPF
AT2 cell
AT2 organoid
Online Access:https://doi.org/10.1186/s12931-024-02786-2

Internet

https://doi.org/10.1186/s12931-024-02786-2

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