Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation

Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation

Abstract Background Gasdermin B (GSDMB) over-expression promotes poor prognosis and aggressive behavior in HER2 breast cancer by increasing resistance to therapy. Decoding the molecular mechanism of GSDMB-mediated drug resistance is crucial to identify novel effective targeted treatments for HER2/GS...

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Bibliographic Details
Main Authors: Manuel Gámez-Chiachio, Ángela Molina-Crespo, Carmen Ramos-Nebot, Jeannette Martinez-Val, Lidia Martinez, Katja Gassner, Francisco J. Llobet, Mario Soriano, Alberto Hernandez, Marco Cordani, Cristina Bernadó-Morales, Eva Diaz, Alejandro Rojo-Sebastian, Juan Carlos Triviño, Laura Sanchez, Ruth Rodríguez-Barrueco, Joaquín Arribas, David Llobet-Navás, David Sarrió, Gema Moreno-Bueno
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Gasdermin B
Protective autophagy
Anti-HER2 therapy
Drug resistance
HER2 breast cancer
Gastroesophageal tumors
Online Access:https://doi.org/10.1186/s13046-022-02497-w

Internet

https://doi.org/10.1186/s13046-022-02497-w

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