Dose Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity
Introduction: Sulfobutylether-b-cyclodextrin (SBE-CD) is a pharmaceutical excipient known to bind verapamil. Following intravenous administration, clearance of SBE-CD approximates glomerular filtration rate. We hypothesized that infusion of SBE-CD would increase time to asystole in a rat model of ve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
eScholarship Publishing, University of California
2012-04-01
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| Series: | Western Journal of Emergency Medicine |
| Subjects: | |
| Online Access: | http://escholarship.org/uc/item/07p476t8 |