Dose Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity

Dose Dependent Response to Cyclodextrin Infusion in a Rat Model of Verapamil Toxicity

Introduction: Sulfobutylether-b-cyclodextrin (SBE-CD) is a pharmaceutical excipient known to bind verapamil. Following intravenous administration, clearance of SBE-CD approximates glomerular filtration rate. We hypothesized that infusion of SBE-CD would increase time to asystole in a rat model of ve...

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Bibliographic Details
Main Authors: Allan R. Mottram, Sean M. Bryant, Steven E. Aks
Format: Article
Language:English
Published: eScholarship Publishing, University of California 2012-04-01
Series:Western Journal of Emergency Medicine
Subjects:
Cyclodextrin
Verapamil
Cardiotoxicity
Rat
Online Access:http://escholarship.org/uc/item/07p476t8

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