Repurposing Bedaquiline for Effective Non-Small Cell Lung Cancer (NSCLC) Therapy as Inhalable Cyclodextrin-Based Molecular Inclusion Complexes

Repurposing Bedaquiline for Effective Non-Small Cell Lung Cancer (NSCLC) Therapy as Inhalable Cyclodextrin-Based Molecular Inclusion Complexes

There is growing evidence that repurposed drugs demonstrate excellent efficacy against many cancers, while facilitating accelerated drug development process. In this study, bedaquiline (BDQ), an FDA approved anti-mycobacterial agent, was repurposed and an inhalable cyclodextrin complex formulation w...

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Bibliographic Details
Main Authors: Vineela Parvathaneni, Rasha S. Elbatanony, Mimansa Goyal, Tejashri Chavan, Nathan Vega, Srikanth Kolluru, Aaron Muth, Vivek Gupta, Nitesh K. Kunda
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
bedaquiline
sulfobutylether-β-cyclodextrin
non-small cell lung cancer
inhalation
molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/9/4783

Internet

https://www.mdpi.com/1422-0067/22/9/4783

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