The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection

The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection

HIV-1 infection is characterized by inflammation and a progressive decline in CD4+ T cell count. Despite treatment with antiretroviral therapy (ART), the majority of people living with HIV (PLWH) maintain residual levels of inflammation, a low degree of immune activation, and higher sensitivity to c...

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Bibliographic Details
Main Authors: Liseth Carmona-Pérez, Xavier Dagenais-Lussier, Linh T. Mai, Tanja Stögerer, Sharada Swaminathan, Stéphane Isnard, Matthew R. Rice, Betsy J. Barnes, Jean-Pierre Routy, Julien van Grevenynghe, Simona Stäger
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-07-01
Series:JCI Insight
Subjects:
AIDS/HIV
Immunology
Online Access:https://doi.org/10.1172/jci.insight.167329

Internet

https://doi.org/10.1172/jci.insight.167329

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