The emerging role of radical chemistry in the amination transformation of highly strained [1.1.1]propellane: Bicyclo[1.1.1]pentylamine as bioisosteres of anilines

The emerging role of radical chemistry in the amination transformation of highly strained [1.1.1]propellane: Bicyclo[1.1.1]pentylamine as bioisosteres of anilines

Bicyclo[1.1.1]pentylamines (BPCAs), emerging as sp3-rich surrogates for aniline and its derivatives, demonstrate unique structural features and physicochemical profiles in medicinal and synthetic chemistry. In recent years, compared with conventional synthetic approaches, the rapid development of ra...

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Bibliographic Details
Main Authors: Qiwen Pang, Yang Li, Xin Xie, Jie Tang, Qian Liu, Cheng Peng, Xiang Li, Bo Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Chemistry
Subjects:
[1.1.1]propellane
bicyclo[1.1.1]pentylamine
radical chemistry
amination
bioisosteres
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.997944/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.997944/full

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