PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL

PNPLA3(I148M) Inhibits Lipolysis by Perilipin-5-Dependent Competition with ATGL

The single nucleotide polymorphism I148M of the lipase <i>patatin-like phospholipase domain containing 3</i> (<i>PNPLA3</i>) is associated with an unfavorable prognosis in alcoholic and non-alcoholic steatohepatitis (ASH, NASH), with progression to liver cirrhosis and develop...

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Bibliographic Details
Main Authors: Hagen Roland Witzel, Inga Maria Gertrud Schwittai, Nils Hartmann, Sebastian Mueller, Jörn M. Schattenberg, Xue-Min Gong, Johannes Backs, Peter Schirmacher, Detlef Schuppan, Wilfried Roth, Beate Katharina Straub
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
PNPLA3
perilipin
NAFLD
lipoloysis
lipid droplets
non-alcoholic steatohepatitis (NASH)
Online Access:https://www.mdpi.com/2073-4409/12/1/73

Internet

https://www.mdpi.com/2073-4409/12/1/73

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