Predictive Simulations in Preclinical Oncology to Guide the Translation of Biologics

Preclinical in vivo studies form the cornerstone of drug development and translation, bridging in vitro experiments with first-in-human trials. However, despite the utility of animal models, translation from the bench to bedside remains difficult, particularly for biologics and agents with unique me...

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Bibliographic Details
Main Authors: Shujun Dong, Ian Nessler, Anna Kopp, Baron Rubahamya, Greg M. Thurber
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.836925/full