Predictive Simulations in Preclinical Oncology to Guide the Translation of Biologics
Preclinical in vivo studies form the cornerstone of drug development and translation, bridging in vitro experiments with first-in-human trials. However, despite the utility of animal models, translation from the bench to bedside remains difficult, particularly for biologics and agents with unique me...
Main Authors: | Shujun Dong, Ian Nessler, Anna Kopp, Baron Rubahamya, Greg M. Thurber |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-03-01
|
Series: | Frontiers in Pharmacology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.836925/full |
Similar Items
-
Practical Guide for Quantification of In Vivo Degradation Rates for Therapeutic Proteins with Single-Cell Resolution Using Fluorescence Ratio Imaging
by: Ian Nessler, et al.
Published: (2020-02-01) -
Analysis of the Effectiveness Factor in a Fixed-Bed Tubular Reactor System: Catalytic Dehydrogenation of Cyclohexanol
by: Luis Américo Carrasco-Venegas, et al.
Published: (2023-03-01) -
Distribution and metabolism of antibodies and macromolecules in tumor tissue
by: Thurber, Greg M
Published: (2008) -
Numerical Study of a Water Gas Shift Fixed Bed Reactor Operating at Low Pressures
by: Wail El-Bazi, et al.
Published: (2022-06-01) -
NUMERICAL SIMULATION OF CARBONATE ROCKS DISSOLUTION NEAR THE WELLBORE
by: Zhibek Kairatovna Akasheva, et al.
Published: (2021-12-01)