Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation.

Long-Term Overexpression of Hsp70 Does Not Protect against Cardiac Dysfunction and Adverse Remodeling in a MURC Transgenic Mouse Model with Chronic Heart Failure and Atrial Fibrillation.

Previous animal studies had shown that increasing heat shock protein 70 (Hsp70) using a transgenic, gene therapy or pharmacological approach provided cardiac protection in models of acute cardiac stress. Furthermore, clinical studies had reported associations between Hsp70 levels and protection agai...

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Bibliografske podrobnosti
Main Authors: Bianca C Bernardo, Geeta Sapra, Natalie L Patterson, Nelly Cemerlang, Helen Kiriazis, Tomomi Ueyama, Mark A Febbraio, Julie R McMullen
Format: Article
Jezik:English
Izdano: Public Library of Science (PLoS) 2015-01-01
Serija:PLoS ONE
Online dostop:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145173&type=printable

Internet

https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0145173&type=printable

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