A genetically stable Zika virus vaccine candidate protects mice against virus infection and vertical transmission

A genetically stable Zika virus vaccine candidate protects mice against virus infection and vertical transmission

Abstract Although live attenuated vaccines (LAVs) have been effective in the control of flavivirus infections, to date they have been excluded from Zika virus (ZIKV) vaccine trials due to safety concerns. We have previously reported two ZIKV mutants, each of which has a single substitution in either...

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Bibliographic Details
Main Authors: Awadalkareem Adam, Camila R. Fontes-Garfias, Vanessa V. Sarathy, Yang Liu, Huanle Luo, Emily Davis, Wenqian Li, Antonio E. Muruato, Binbin Wang, Renat Ahatov, Yoseph Mahmoud, Chao Shan, Samantha R. Osman, Steven G. Widen, Alan D. T. Barrett, Pei-Yong Shi, Tian Wang
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00288-6

Internet

https://doi.org/10.1038/s41541-021-00288-6

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