Tracking Immunoglobulin Repertoire and Transcriptomic Changes in Germinal Center B Cells by Single-Cell Analysis

Tracking Immunoglobulin Repertoire and Transcriptomic Changes in Germinal Center B Cells by Single-Cell Analysis

In response to T-cell-dependent antigens, mature B cells in the secondary lymphoid organs are stimulated to form germinal centers (GCs), which are histological structures deputed to antibody affinity maturation, a process associated with immunoglobulin gene editing by somatic hypermutation (SHM) and...

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Bibliographic Details
Main Authors: Clarissa Corinaldesi, Antony B. Holmes, Qiong Shen, Eli Grunstein, Laura Pasqualucci, Riccardo Dalla-Favera, Katia Basso
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
germinal center
single-cell analysis
gene expression
memory B cells
plasma cells
B cell receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.818758/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.818758/full

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