Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons

Aberrant axon initial segment plasticity and intrinsic excitability of ALS hiPSC motor neurons

Summary: Dysregulated neuronal excitability is a hallmark of amyotrophic lateral sclerosis (ALS). We sought to investigate how functional changes to the axon initial segment (AIS), the site of action potential generation, could impact neuronal excitability in ALS human induced pluripotent stem cell...

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Bibliographic Details
Main Authors: Peter Harley, Caoimhe Kerins, Ariana Gatt, Guilherme Neves, Federica Riccio, Carolina Barcellos Machado, Aimee Cheesbrough, Lea R’Bibo, Juan Burrone, Ivo Lieberam
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015218

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http://www.sciencedirect.com/science/article/pii/S2211124723015218

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