Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis

Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis

The RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates.

Bibliographic Details
Main Authors: Xin Liu, Tao Sun, Anna Shcherbina, Qin Li, Inga Jarmoskaite, Kalli Kappel, Gokul Ramaswami, Rhiju Das, Anshul Kundaje, Jin Billy Li
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22489-2

Internet

https://doi.org/10.1038/s41467-021-22489-2

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