Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis
The RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates.
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-22489-2 |
| _version_ | 1818858281355968512 |
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| author | Xin Liu Tao Sun Anna Shcherbina Qin Li Inga Jarmoskaite Kalli Kappel Gokul Ramaswami Rhiju Das Anshul Kundaje Jin Billy Li |
| author_facet | Xin Liu Tao Sun Anna Shcherbina Qin Li Inga Jarmoskaite Kalli Kappel Gokul Ramaswami Rhiju Das Anshul Kundaje Jin Billy Li |
| author_sort | Xin Liu |
| collection | DOAJ |
| description | The RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates. |
| first_indexed | 2024-12-19T08:53:48Z |
| format | Article |
| id | doaj.art-f291ffe598744dbb9b94da4931988805 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:53:48Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f291ffe598744dbb9b94da49319888052022-12-21T20:28:39ZengNature PortfolioNature Communications2041-17232021-04-0112111710.1038/s41467-021-22489-2Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesisXin Liu0Tao Sun1Anna Shcherbina2Qin Li3Inga Jarmoskaite4Kalli Kappel5Gokul Ramaswami6Rhiju Das7Anshul Kundaje8Jin Billy Li9Department of Genetics, Stanford UniversityDepartment of Genetics, Stanford UniversityDepartment of Biomedical Data Science, Stanford UniversityDepartment of Genetics, Stanford UniversityDepartment of Genetics, Stanford UniversityBiophysics Program, Stanford UniversityDepartment of Genetics, Stanford UniversityDepartment of Biochemistry, Stanford UniversityDepartment of Genetics, Stanford UniversityDepartment of Genetics, Stanford UniversityThe RNA sequence and secondary structure regulate RNA editing by ADAR. Here the authors employ a CRISPR/Cas9-mediated saturation mutagenesis and machine learning to predict RNA editing efficiency of specific substrates.https://doi.org/10.1038/s41467-021-22489-2 |
| spellingShingle | Xin Liu Tao Sun Anna Shcherbina Qin Li Inga Jarmoskaite Kalli Kappel Gokul Ramaswami Rhiju Das Anshul Kundaje Jin Billy Li Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis Nature Communications |
| title | Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis |
| title_full | Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis |
| title_fullStr | Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis |
| title_full_unstemmed | Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis |
| title_short | Learning cis-regulatory principles of ADAR-based RNA editing from CRISPR-mediated mutagenesis |
| title_sort | learning cis regulatory principles of adar based rna editing from crispr mediated mutagenesis |
| url | https://doi.org/10.1038/s41467-021-22489-2 |
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